Format

Send to

Choose Destination
Biochim Biophys Acta. 2004 Nov 11;1694(1-3):37-53.

Sec-translocase mediated membrane protein biogenesis.

Author information

1
Department of Chemistry, The Ohio State University, 120 W. 18th Avenue, Columbus, OH 43210-1106, USA. dalbey@chemistry.ohio-state.edu <dalbey@chemistry.ohio-state.edu>

Abstract

Alpha-helical transmembrane proteins in bacteria are localized within the plasma membrane. The membrane assembly of these proteins requires protein devices for insertion into the lipid bilayer. In E. coli, membrane proteins require the SRP pathway components Ffh, 4.5S RNA and FtsY for membrane targeting and the SecYEGDF translocase and, in some cases, SecA, for translocation of hydrophilic domains. In addition, YidC, a recently discovered membrane protein, mediates the membrane integration and folding of hydrophobic domains of membrane proteins. In this review, we will describe the current status of the protein targeting and membrane integration pathways.

PMID:
15546656
DOI:
10.1016/j.bbamcr.2004.03.009
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center