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Br J Obstet Gynaecol. 1992 Feb;99(2):109-11.

The treatment of intrahepatic cholestasis of pregnancy by dexamethasone.

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1
Department of Obstetrics and Gynecology, University of Tampere, Finland.

Abstract

OBJECTIVE:

To investigate whether dexamethasone suppression of fetoplacental oestrogen production can reduce obstetric cholestasis.

DESIGN:

Observational study.

SETTING:

Department of Obstetrics and Gynaecology, University of Tampere, Finland.

SUBJECTS:

10 women, at between 28 and 37 weeks gestation, with intrahepatic cholestasis of pregnancy.

INTERVENTIONS:

Treatment with 12 mg oral dexamethasone daily for 7 days, after which the therapy was gradually discontinued over 3 days.

MAIN OUTCOME MEASURES:

Serum oestriol, oestradiol, total bile acids and ALAT were measured before and during therapy and on days 4 and 7 and ALAT also on day 12. Differences were tested by paired t test.

RESULTS:

Itching disappeared or was relieved in all patients. Serum oestriol level fell significantly by day 1 of treatment, serum oestradiol and total bile acid levels by day 4 and ALAT by day 12 from the beginning of the therapy.

CONCLUSION:

Dexamethasone is a drug of choice in the treatment of intrahepatic cholestasis of pregnancy.

PMID:
1554659
[Indexed for MEDLINE]
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