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Am J Surg. 2004 Nov;188(5):491-4.

Effects of surgical gloves on postoperative peritoneal adhesions and cytokine expression in a rat model.

Author information

1
Department of Surgery, North Oakland Medical Centers, Department of Surgical Education, 461 W. Huron, Pontiac, MI 48341, USA. amitdwivedi@hotmail.com

Abstract

BACKGROUND:

Postoperative intraperitoneal adhesions are a major cause of morbidity. We studied the effects of synthetic and latex gloves, and their powders, on postoperative adhesions and cytokine expression in a rat model.

METHODS:

Rats underwent laparotomy and cecal abrasion. Rats were grouped based on the glove type used: synthetic powder-free (SPF), synthetic powdered (SP), latex powder-free (LPF), and latex powdered (LP). Serum cytokine (tumor necrosis factor [TNF], interleukin-1 [IL-1], and IL-6) levels were measured. Animals were killed and peritoneal adhesions were graded.

RESULTS:

The SPF group had no adhesions. Adhesions were increased similarly in the SP and LPF groups, and further increased in the LP group. Postoperative serum cytokine levels showed a similar pattern of increases.

CONCLUSIONS:

The presence of latex or powder on surgical gloves promoted increased adhesions. Serum cytokine levels correlated with the degree of adhesion formation. Strategies to use latex-free, powder-free gloves and/or limit cytokine expression may decrease peritoneal adhesions in the clinical setting.

PMID:
15546556
DOI:
10.1016/j.amjsurg.2004.07.019
[Indexed for MEDLINE]

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