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Immunol Rev. 2004 Dec;202:223-36.

Interleukin-10 in viral diseases and cancer: exiting the labyrinth?

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1
Schering-Plough Laboratory for Immunological Research, Dardilly, France. alain.vicari@spcorp.com

Abstract

Interleukin-10 (IL-10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL-10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.

[Indexed for MEDLINE]

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