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Immunol Rev. 2004 Dec;202:203-22.

Signaling pathways in Th2 development.

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Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.


In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.

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