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J Clin Invest. 2004 Nov;114(10):1398-403.

Tregs and transplantation tolerance.

Author information

1
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA.

Abstract

The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. This review outlines our current understanding of the Treg subsets that contribute to allotolerance and the mechanisms by which these cells exert their effects as well as their potential for therapy.

PMID:
15545987
PMCID:
PMC525747
DOI:
10.1172/JCI23238
[Indexed for MEDLINE]
Free PMC Article

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