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Genetics. 2005 Feb;169(2):1133-46. Epub 2004 Nov 15.

The genomes of recombinant inbred lines.

Author information

1
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA. kbroman@jhsph.edu

Erratum in

  • Genetics. 2006 Aug;173(4):2419.

Abstract

Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.

PMID:
15545647
PMCID:
PMC1449115
DOI:
10.1534/genetics.104.035212
[Indexed for MEDLINE]
Free PMC Article

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