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Genes Dev. 2004 Nov 15;18(22):2730-5.

Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.

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  • 1INSERM E365, Faculté de Médecine Lariboisière, Paris 75010, France.

Abstract

Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3-/- mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3-/- mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC.

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