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Cancer Cell. 2004 Nov;6(5):447-58.

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis.

Author information

1
Graduate Program in Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

Abstract

The role of Ras oncogenes in promoting cellular transformation is well established. However, the contribution of Ras signaling to interactions between tumor cells and their host environment remains poorly characterized. Here, we demonstrate that the inflammatory mediator interleukin-8 (CXCL-8/IL-8) is a transcriptional target of Ras signaling. Using a tumor xenograft model, we show that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization. Collectively, our data identify a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression.

PMID:
15542429
DOI:
10.1016/j.ccr.2004.09.028
[Indexed for MEDLINE]
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