Send to

Choose Destination
Forensic Sci Int. 2004 Dec 16;146(2-3):97-104.

Long-term intracerebral inflammatory response after traumatic brain injury.

Author information

Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK. <>


Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center