Format

Send to

Choose Destination
See comment in PubMed Commons below
Vaccine. 2004 Dec 16;23(5):615-22.

Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response.

Author information

1
Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C.M.U., 1 rue Michel-Servet, 1211 Geneva 4, Switzerland. Claire-Anne.Siegrist@medecine.unige.ch

Abstract

We assessed the avidity maturation process elicited by human immunization with alum-adsorbed HBsAg alone or with a novel adjuvant containing CpG motifs (CpG 7909). Mean avidity indexes and distribution of low- and high-avidity anti-HBs indicated that avidity maturation essentially takes place late after priming. CpG 7909 markedly enhanced this affinity maturation process, increasing the pool of high-avidity antibodies. The influence of CpG 7909 was antigen-specific, isotype-specific and distinct from the influence on anti-HBs production, as avidity did not correlate with anti-HBs IgG titers. This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity.

PMID:
15542181
DOI:
10.1016/j.vaccine.2004.07.014
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center