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Eur J Obstet Gynecol Reprod Biol. 2004 Dec 1;117(2):227-35.

Longitudinal and cross-sectional studies of HIV-1 RNA and DNA loads in blood and the female genital tract.

Author information

1
Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9AD, UK. aiversen@hammer.imm.ox.ac.uk

Abstract

OBJECTIVE:

To examine if correlates of HIV-1 genital shedding in cross-sectional studies can be used to determine the risk of shedding in individual HIV-1-positive women.

STUDY DESIGN:

Longitudinal samples from blood and cervix were obtained from 18 HIV-1 infected women, and HIV-1 RNA and cell-associated DNA virus, and beta-chemokine levels, were measured. Associations between variables were analyzed at both individual and group level.

RESULTS:

The variation over time was 2.9-, 2.1-, and 2.3-fold in plasma RNA, PBMC DNA and cervical RNA load, respectively, and reached 6.2-fold in cervical DNA load. Differences were observed between associations in individual- and group-level comparisons, suggesting that a separate reservoir of HIV replication may exist in the genital tract of some women, which is influenced by local environmental factors.

CONCLUSIONS:

Our study underscores the importance of caution during contact with genital fluids at all stages of infection and disease regardless of treatment and HIV-1 blood loads.

PMID:
15541862
DOI:
10.1016/j.ejogrb.2004.05.016
[Indexed for MEDLINE]

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