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Am J Hum Genet. 2005 Jan;76(1):1-7. Epub 2004 Nov 11.

Prospects for admixture mapping of complex traits.

Author information

1
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. paul.mckeigue@ucd.ie

Abstract

Admixture mapping extends to human populations the principles that underlie linkage analysis of an experimental cross. For detecting genes that contribute to ethnic variation in disease risk, admixture mapping has greater statistical power than family-linkage studies. In comparison with association studies, admixture mapping requires far fewer markers to search the genome and is less affected by allelic heterogeneity. Statistical-analysis programs for admixture mapping are now available, and a genomewide panel of markers for admixture mapping in populations formed by West African-European admixture has been assembled. Some of the remaining technical challenges include the ability to ensure that the statistical methods are robust and to develop marker panels for other admixed populations. Where admixed populations and panels of markers informative for ancestry are available, admixture mapping can be applied to localize genes that contribute to ethnic variation in any measurable trait.

PMID:
15540159
PMCID:
PMC1196412
DOI:
10.1086/426949
[Indexed for MEDLINE]
Free PMC Article

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