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Cancer Biol Ther. 2004 Nov;3(11):1045-50. Epub 2004 Nov 22.

Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis.

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Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.


Inappropriate activation of transcription factors is a common event in cancer. These transcription factors contribute to a malignant phenotype by regulating genes involved in cellular proliferation, survival, differentiation, angiogenesis, and invasion. An important goal remains identifying the targets of oncogenic transcription factors that execute these changes. STAT proteins are among the best-studied of these transcription factors, and are involved in oncogenesis both in vivo and in vitro. They thus represent an ideal model for understanding how transcription factors cause cancer through coordinated changes in gene expression. Recent studies have employed microarray-based expression analysis to comprehensively identify STAT target genes. Analysis of these targets can provide insight into mechanisms of neoplastic transformation, and may shed light on new strategies for targeted therapy.

[Indexed for MEDLINE]

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