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J Physiol. 2005 Jan 1;562(Pt 1):89-97. Epub 2004 Nov 11.

Excitatory and inhibitory connections show selectivity in the neocortex.

Author information

1
Department of Pharmacology, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. joanne.watts@ulsop.ac.uk

Abstract

The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and distinctions between excitatory and inhibitory pathways. The 'feedforward' projections from layer 4-3 and from 3-5 target pyramidal cells and to lesser degrees interneurones. 'Feedback' projections from layer 5-3 and from 3-4, on the other hand, mainly target interneurones. Understanding the microcircuitry may give some insight into the computation and information processing performed in this brain region.

PMID:
15539397
PMCID:
PMC1665474
DOI:
10.1113/jphysiol.2004.076984
[Indexed for MEDLINE]
Free PMC Article

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