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J Heart Lung Transplant. 2004 Nov;23(11):1252-9.

Donor-recipient gender mismatch in lung transplantation: impact on obliterative bronchiolitis and survival.

Author information

1
Pulmonary and Critical Care Unit, General Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract

BACKGROUND:

Because of the shortage of donor lungs, liberalization of donor selection criteria in terms of age, gas exchange, and smoking history has been proposed.

METHODS:

We evaluated a single-institution population of lung transplant recipients (n = 98) for donor-recipient gender matching. We measured overall survival, time to acute allograft rejection, and time to development of obliterative bronchiolitis (OB).

RESULTS:

We found significant improvement in overall survival for gender-mismatched donor and recipient pairs (p = 0.078) and a significantly shorter OB-free period for male donor and female recipient pairs (p = 0.017).

CONCLUSION:

These findings suggest that donor organ allocation based on gender may affect long-term survival and other outcomes after lung transplantation.

PMID:
15539123
DOI:
10.1016/j.healun.2003.09.014
[Indexed for MEDLINE]

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