Format

Send to

Choose Destination
J Med Chem. 2004 Nov 18;47(24):5833-6.

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

Author information

1
Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. eva.altmann@pharma.novartis.com

Abstract

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.

PMID:
15537340
DOI:
10.1021/jm0493111
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center