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Eur J Clin Nutr. 2005 Mar;59(3):456-8.

Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.

Author information

1
Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, Republic of Korea.

Abstract

OBJECTIVE:

To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.

DESIGN:

Randomized, double-blind, placebo-controlled, parallel-group trial.

SETTING:

Pusan Paik Hospital, Pusan, Republic of Korea.

INTERVENTIONS:

A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.

RESULTS:

Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).

CONCLUSIONS:

These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.

PMID:
15536472
DOI:
10.1038/sj.ejcn.1602081
[Indexed for MEDLINE]

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