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Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16642-7. Epub 2004 Nov 9.

Human cytomegalovirus encodes a highly specific RANTES decoy receptor.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Abstract

The human cytomegalovirus pUL21.5 protein is a small, secreted glycoprotein whose mRNA is packaged into virions. We demonstrate that pUL21.5 protein is a soluble CC chemokine receptor that functions as a decoy to modulate the host immune response to infection. In contrast to other viral chemokine-binding proteins, which interact promiscuously with multiple chemokines, pUL21.5 selectively binds RANTES (regulated upon activation, normal T cell expressed and secreted) with high affinity. By binding RANTES, pUL21.5 blocks RANTES interaction with its cellular receptors. We propose that human cytomegalovirus directs the synthesis of a secreted, virus-coded protein that modulates the host antiviral response even before the newly infecting viral genome becomes transcriptionally active.

PMID:
15536129
PMCID:
PMC534536
DOI:
10.1073/pnas.0407233101
[Indexed for MEDLINE]
Free PMC Article

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