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Gene Expr Patterns. 2004 Nov;5(1):107-12.

gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish.

Author information

  • 1Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403-1254, USA. sarahc@uoneuro.uoregon.edu

Abstract

We have cloned and characterized the expression of zebrafish genetic screen homeobox 1 (gsh1). Early expression is confined to hindbrain rhombomeres; by mid-somitogenesis gsh1 is expressed in precise domains within the mesencephalon and diencephalon, as well as in intermediate spinal cord. Double-label experiments revealed that the diencephalic domain is coincident with hypothalamus and that spinal cord expression is in a region that generates interneurons. These data suggest gsh1 may play a role in patterning cell types generated in these domains.

PMID:
15533825
DOI:
10.1016/j.modgep.2004.05.006
[PubMed - indexed for MEDLINE]
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