Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Neurol. 2004 Dec;190(2):544-7.

Focally injected adenosine prevents seizures in the rat.

Author information

  • 1Comprehensive Epilepsy Center, Department of Neurology, Stanford University Medical Center, Stanford, CA 94305-5235, USA.

Abstract

Prophylactic drug injection directly onto a seizure focus has the potential to improve seizure control with fewer side effects than is produced by systemic therapy. Using a dose-response model, we evaluated the effectiveness of adenosine application for focal seizure prophylaxis in 12 rats. Total spikes and electroencephalographic ictal events were reduced significantly by treatment with adenosine compared to control (P < 0.0001). This study demonstrates effectiveness and feasibility in a model system using intracranial injection of adenosine to prevent epileptiform events.

PMID:
15530893
DOI:
10.1016/j.expneurol.2004.07.017
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center