Format

Send to

Choose Destination
Curr Opin Cell Biol. 2004 Dec;16(6):647-52.

Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.

Author information

1
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.

Abstract

Mitochondria play an important role in the integration and transmission of cell death signals, activating caspases and other cell death execution events by releasing apoptogenic proteins from the intermembrane space. The BCL-2 family of proteins localize (or can be targeted) to mitochondria and regulate the permeability of the mitochondrial outer membrane to these apoptotic factors. Recent evidence suggests that multiple mechanisms may regulate the release of mitochondrial factors, some of which depend on the action of caspases.

PMID:
15530776
DOI:
10.1016/j.ceb.2004.09.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center