Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Pharmacol Sci. 2004 Dec;25(12):613-7.

Bad news from the brain: descending 5-HT pathways that control spinal pain processing.

Author information

1
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. ucklrsu@ucl.ac.uk

Abstract

The identification of opioid systems led to much of the early work on pain pharmacology being based on understanding inhibitory mechanisms of analgesia. However, hyperalgesia and allodynia are common clinical symptoms and therefore hyperexcitability must be a major component of pain. Thus, the emphasis of current research into pain has shifted to understanding excitatory pathways that underlie neuronal sensitization and potentiation. Although much evidence supports the presence of descending inhibitory mechanisms of pain, reports of facilitatory pathways from the brainstem have been scarce. In this article, we review evidence for facilitatory 5-HT pathways that link spinal cord and brainstem areas involved in mood and emotions. Because pain encompasses affective aspects, we suggest that these 5-HT pathways and other circuits are important in determining the levels of pain, the outcome of drug treatments and provide a mechanism whereby emotions can alter pain perception.

PMID:
15530638
DOI:
10.1016/j.tips.2004.10.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center