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Nat Biotechnol. 2004 Nov;22(11):1457-8.

How do RNA folding algorithms work?

Author information

1
Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. eddy@genetics.wustl.edu

Abstract

Programs such as MFOLD and ViennaRNA are widely used to predict RNA secondary structures. How do these algorithms work? Why can't they predict RNA pseudoknots? How accurate are they, and will they get better?

PMID:
15529172
DOI:
10.1038/nbt1104-1457
[Indexed for MEDLINE]

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