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Science. 2004 Nov 5;306(5698):1037-40.

Autophagy defends cells against invading group A Streptococcus.

Author information

1
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan. ichiro@dent.osaka-u.ac.jp

Abstract

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

PMID:
15528445
DOI:
10.1126/science.1103966
[Indexed for MEDLINE]
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