Send to

Choose Destination
Ren Fail. 2004 Sep;26(5):539-44.

Effect of exercise training on interdialytic ambulatory and treatment-related blood pressure in hemodialysis patients.

Author information

Division of Renal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.



Exercise training improves blood pressure (BP) in the general population, but prior studies in hemodialysis (HD) patients only used pill counts or treatment-related BPs. We evaluated the effect of 3 to 6 months of intradialytic exercise training on ambulatory blood pressure (ABP) and treatment-related pre- and postdialysis BP.


Nineteen chronic HD patients trained with an exercise bicycle for 30 to 60 min in the first 1 to 2 hr of each of thrice weekly HD. Interdialytic 44-hr ABP was performed a week before training began and repeated at 3 and 6 months. Pre- and post-HD systolic and diastolic BP and pre- and post-HD weight were recorded for 2 months prior to training, throughout the training, and, if available, for the 2 months after training ended. BP medications were recorded throughout. Body composition by bioimpedance, and norepinephrine and epinephrine levels by RIA were done at 0, 3, and 6 months.


Thirteen subjects who completed at least 3 months of training exercised 90% of HD sessions for 56 min +/- 23 SD each. Systolic and diastolic 44-hr interdialytic ABP fell during training (systolic 138.4 mmHg +/- 19.6 vs. 125.7 mmHg +/- 20.0 vs. 125.9 mmHg +/- 22.9; diastolic 83.2 mmHg +/- 10.2 vs. 74.7 mmHg +/- 9.0 vs. 73.9 mmHg +/- 11.8 at 0, 3, and 6 months; p < .05 ANOVA). Norepinephrine and epinephrine levels did not independently predict systolic BP. Pre-HD systolic BP was stable during the pretraining period, fell significantly during the training period (p < .03), and returned toward preexercise levels during the posttraining period (p < .001). Pre- or postweight, erythropoietin dose, total body water, and number of BP meds were unchanged.


Exercise training during HD significantly improves both interdialytic ABP and treatment-related BP.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center