[Protective effect of ganfukang capsule on hepatocytes in rats with experimental hepatic fibrosis]

Ying Che; Tingting Xu; Miaona Jiang; Yujie Jia

[Protective effect of ganfukang capsule on hepatocytes in rats with experimental hepatic fibrosis]

Zhong Yao Cai. 2004 Jun;27(6):428-9.

[Article in Chinese]

Authors

Ying Che¹, Tingting Xu, Miaona Jiang, Yujie Jia

Affiliation

¹ The First Affiliated Hospital of Dalian Medical University.

PMID: 15524298

Abstract

Objective: To observe the protective effect of ganfukang capsule on hepatocytes of rats with experimental hepatic fibrosis rat.

Method: SD rat model of liver fibrosis was induced by CCl4. The effect of ganfukang capsule on liver function, histological change and ultrastructural were examined.

Results: Liver function, histological change and ultrastructural were significantly improved. The degree of steatosis was significantly decreased.

Conclusion: Ganfukang capsule might protect hepatocytes, mitochondria from the injury induced by CCl4 and improve liver function.

Publication types

English Abstract

MeSH terms

Alanine Transaminase / blood
Animals
Aspartate Aminotransferases / blood
Capsules
Carbon Tetrachloride Poisoning
Drug Combinations
Drugs, Chinese Herbal / pharmacology*
Female
Hepatocytes / drug effects*
Hepatocytes / pathology
Liver Cirrhosis, Experimental / chemically induced
Liver Cirrhosis, Experimental / metabolism
Liver Cirrhosis, Experimental / pathology*
Liver Function Tests
Protective Agents / pharmacology*
Rats
Rats, Sprague-Dawley

Substances

Capsules
Drug Combinations
Drugs, Chinese Herbal
Protective Agents
Aspartate Aminotransferases
Alanine Transaminase