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Nat Struct Mol Biol. 2004 Nov;11(11):1044-8.

Assembling the mitochondrial outer membrane.

Author information

1
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany. Nikolaus.Pfanner@biochemie.uni-freiburg.de <Nikolaus.Pfanner@biochemie.uni-freiburg.de>

Abstract

The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.

PMID:
15523480
DOI:
10.1038/nsmb852
[Indexed for MEDLINE]

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