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Semin Immunol. 2004 Aug;16(4):277-81.

A bird's eye view on human B cells.

Author information

1
INSERM U373, Faculté de Médecine Necker-Enfants Malades, Université Paris V, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. weill@necker.fr

Abstract

We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for one B-cell subpopulation, the marginal zone B-cell subset in charge of T-independent responses, the strategies of diversification used by GALT species to generate their pre-immune repertoire.

PMID:
15522625
DOI:
10.1016/j.smim.2004.08.007
[Indexed for MEDLINE]
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