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J Clin Invest. 2004 Nov;114(9):1209-17.

CD4+ Tregs and immune control.

Author information

1
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. zed72@frontier.kyoto-u.ac.jp

Abstract

Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.

PMID:
15520849
PMCID:
PMC524236
DOI:
10.1172/JCI23395
[Indexed for MEDLINE]
Free PMC Article

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