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Nat Rev Mol Cell Biol. 2004 Nov;5(11):886-96.

Targeting Rab GTPases to distinct membrane compartments.

Author information

1
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA. pfeffer@stanford.edu

Abstract

Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.

PMID:
15520808
DOI:
10.1038/nrm1500
[Indexed for MEDLINE]

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