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Seizure. 2004 Dec;13(8):534-6.

Antiepileptic drug treatment in seizure-free mesial temporal lobe epilepsy patients with hippocampal sclerosis following selective amygdalohippocampectomy.

Author information

1
Department of Epileptology and Electroencephalography, Neurology Clinic, University Hospital Zurich, Zurich, Switzerland. hgwepi@neurol.unizh.ch

Abstract

Retrospectively we analysed postoperative AED treatment in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) who were seizure free following selective amygdalohippocampectomy (AHE). In this subgroup, we compared the patients without AEDs with that in the entire series.

RESULTS:

During the year prior to surgery, in the MTLE-HS group, a mean of 2.3 +/- 0.8 AEDs were taken. The percentage of seizure-free MTLE-HS patients without AEDs increases to 40% from the postoperative year 5 on. In the ILAE Class 1a (seizure- and aura-free since surgery) at postoperative year 5 more than 60% and from postoperative year 7 on more than 90% have discontinued AED intake.

CONCLUSION:

These figures indicate that reduction and discontinuation of AEDs is the same in the subgroup "seizure-free MTLE-HS patients" compared to the entire series.

PMID:
15519912
DOI:
10.1016/j.seizure.2003.12.010
[Indexed for MEDLINE]
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