Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2004 Nov;14(11):589-93.

Magic touch: how does cell-cell adhesion trigger actin assembly?

Author information

1
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. alexander.bershadsky@weimann.ac.il

Abstract

The formation of cadherin-mediated cell-cell junctions is accompanied by a profound remodeling of the actin cytoskeleton. The Arp2/3 complex and its activator cortactin drive the assembly of branching actin-filament arrays, and formin-1 promotes the nucleation of non-branching actin filaments. Recruitment of these actin nucleators to nascent adhesions, formation of the links between them and the cytoplasmic cadherin domain, and triggering of their actin-polymerizing functions are vital steps in the development of cell-cell junctions. In this article, I discuss recent results showing that proteins involved in the regulation of actin polymerization have crucial roles in the development and maintenance of the cadherin junctions.

PMID:
15519846
DOI:
10.1016/j.tcb.2004.09.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center