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Biol Cell. 2004 Oct;96(8):603-15.

Rearrangement of nuclear ribonucleoprotein (RNP)-containing structures during apoptosis and transcriptional arrest.

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1
Department of Animal Biology, Laboratory of Cell Biology and Neurobiology, University of Pavia, Italy. macrobig@unipv.it

Abstract

The aim of this paper is to review the data in the literature concerning ribonucleoprotein components during apoptosis, where a major rearrangement of RNPs takes place. In parallel with chromatin changes, the nucleoplasmic constituents (perichromatin fibrils; perichromatin granules; interchromatin granules and nuclear bodies) as well as the nucleoli aggregate into heterogeneous clusters called HERDS, in the interchromatin space. Later, these RNP-containing structures are extruded from the nucleus and leave the cell within cytoplasmic blebs. We propose also a role for HERDS as markers of irreversible transcriptional arrest.

PMID:
15519695
DOI:
10.1016/j.biolcel.2004.04.013
[Indexed for MEDLINE]
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