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J Bacteriol. 1992 Apr;174(7):2398-403.

Impaired cell division and sporulation of a Bacillus subtilis strain with the ftsA gene deleted.

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Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.


The ftsZ and ftsA genes of Bacillus subtilis are organized in a simple operon expressed from promoter sequences immediately upstream of ftsA. The promoter-distal ftsZ gene is an essential septation gene. In this report, it is shown that the promoter-proximal ftsA gene can be deleted in a previously constructed strain in which the essential gene, ftsZ, is under the control of the inducible spac promoter. Absence of the ftsA gene product resulted in a very filamentous morphology indicating an important role for ftsA in cell division. Also, growth was severely impaired, and viability and sporulation were reduced. The defective sporulation phenotype correlated with a deficiency in the processing of pro-sigma E to its active form.

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