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Nat Genet. 2004 Dec;36(12):1255-7. Epub 2004 Oct 31.

Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.

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Institute of Computer Science, Friedrich-Schiller-University Jena, Chair for Bioinformatics, Ernst-Abbe-Platz 2, 07743 Jena, Germany.

Erratum in

  • Nat Genet. 2005 Jan;37(1):106.


Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.

[Indexed for MEDLINE]

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