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Obstet Gynecol. 2004 Nov;104(5 Pt 2):1208-10.

Detection of fetal lactate with two-dimensional-localized proton magnetic resonance spectroscopy.

Author information

1
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA. JNRobinson@partners.org

Abstract

BACKGROUND:

Antenatal surveillance is inefficient for accurately detecting fetal compromise. A noninvasive technique for assessing fetal metabolic status would be useful for clinical management.

CASE:

Fetal magnetic resonance spectroscopy was performed at 20 weeks in a pregnancy complicated by severe intrauterine growth restriction to determine if lactate, a metabolite associated with fetal hypoxia, was present. Two-dimensional, single-slice proton magnetic resonance spectroscopy was carried out at 1.5 T using a volume-selective, double-spin echo technique. Lactate was detected in fetal back muscle. Fetal death occurred the next day.

CONCLUSIONS:

Although this initial report is purely experimental, further development of this technique may prove to be a valuable noninvasive tool in the management of suspected fetal hypoxia.

[Indexed for MEDLINE]

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