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Scand J Rheumatol Suppl. 2004;119:19-23.

Analgesic effects of 5-HT3 receptor antagonists.

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Max Planck Institute of Psychiatry, Munich, Germany.


Current research suggests an involvement of 5-HT3 receptors in peripheral and central perception and processing of pain as well as in inflammation. Tropisetron and other selective 5-HT3 receptor antagonists have been used successfully for pain reduction and treatment of related symptoms in patients diagnosed with fibromyalgia. This article proposes a concept of the underlying pathophysiology and mechanisms of action of 5-HT3 receptor antagonists in the context of the relevant clinical data on their application in patients with rheumatic disease.

[Indexed for MEDLINE]

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