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Dev Biol. 1992 Apr;150(2):372-80.

Cell proliferation and rearrangement in the development of the malpighian tubules of the hemipteran, Rhodnius prolixus.

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Department of Zoology, University of Cambridge, United Kingdom.


The pattern of cell activities resulting in the generation of a simple tubular epithelium, the Malpighian tubules of Rhodnius prolixus, is examined during embryogenesis. The anlage of the tubules is shown to be of ectodermal origin. An evolving pattern of cycling cells in the primordia is revealed using the immunocytochemical localization of a substituted nucleotide, BUdR. A cell unique to each tubule is shown not to enter the cell cycle but to be required for the proliferation of the remaining cells in the tubules. Furthermore, the activity of this cell imposes on each tubule a clear proximo-distal axis.

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