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Am J Psychiatry. 2004 Nov;161(11):2126-8.

Functional neuroimaging evidence for hyperarousal in insomnia.

Author information

1
Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213-2593, USA. nofzingerea@upmc.edu

Abstract

OBJECTIVE:

The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia.

METHOD:

[(18)F]Fluorodeoxyglucose positron emission tomography was used to assess regional cerebral glucose metabolism of seven patients with insomnia and 20 healthy subjects.

RESULTS:

Compared with healthy subjects, patients with insomnia showed greater global cerebral glucose metabolism during sleep and while awake, a smaller decline in relative metabolism from waking to sleep states in wake-promoting regions, and reduced relative metabolism in the prefrontal cortex while awake.

CONCLUSIONS:

Subjectively disturbed sleep in patients with insomnia is associated with greater brain metabolism. The inability to fall asleep may be related to a failure of arousal mechanisms to decline in activity from waking to sleep states. Further, daytime fatigue may reflect decreased activity in the prefrontal cortex resulting from inefficient sleep.

PMID:
15514418
DOI:
10.1176/appi.ajp.161.11.2126
[Indexed for MEDLINE]
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