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Science. 2004 Oct 29;306(5697):862-5.

A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux.

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1
Developmental Genetics, Center for Molecular Biology of Plants, University Tübingen, Auf der Morgenstelle 3, D-72076 Tübingen, Germany.

Abstract

Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes.

PMID:
15514156
DOI:
10.1126/science.1100618
[Indexed for MEDLINE]
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