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Acta Paediatr. 2004 Nov;93(11):1443-5. doi: 10.1111/j.1651-2227.2004.tb02626.x.

Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children.

Author information

1
Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. meenusingh4@rediffmail.com

Abstract

AIM:

To compare intrapleural streptokinase and placebo in paediatric empyema.

METHODS:

Children with empyema greater than stage 5 received intrapleural streptokinase (n = 19) or normal saline (n = 21) along with intercostal drainage. Clinical and serial sonographic outcomes were compared.

RESULTS:

Although there was no difference in clinical and sonographic outcome, none of the children with stage 7 empyema (multi-loculated empyema) who received streptokinase developed pleural thickening 30 d later.

CONCLUSION:

There is no short-term clinical benefit of intrapleural streptokinase in paediatric empyema; this therapy may be reserved for those with stage 7 empyema to prevent pleural thickening in the long term.

[Indexed for MEDLINE]

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