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Acta Paediatr. 2004 Nov;93(11):1443-5. doi: 10.1111/j.1651-2227.2004.tb02626.x.

Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children.

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Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.



To compare intrapleural streptokinase and placebo in paediatric empyema.


Children with empyema greater than stage 5 received intrapleural streptokinase (n = 19) or normal saline (n = 21) along with intercostal drainage. Clinical and serial sonographic outcomes were compared.


Although there was no difference in clinical and sonographic outcome, none of the children with stage 7 empyema (multi-loculated empyema) who received streptokinase developed pleural thickening 30 d later.


There is no short-term clinical benefit of intrapleural streptokinase in paediatric empyema; this therapy may be reserved for those with stage 7 empyema to prevent pleural thickening in the long term.

[Indexed for MEDLINE]

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