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Ocul Immunol Inflamm. 2004 Jun;12(2):87-99.

Clinical mini-review: systemic lupus erythematosus and the eye.

Author information

1
Department of Ophthalmology and Pathology, University of Alabama at Birmingham, AL 35233, USA. rwr@uab.edu

Abstract

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, the exact etiology of which is unknown. It is characterized by the production of pathological autoantibodies which adhere to cellular surfaces or form immune complexes which deposit in tissue, leading to end-organ damage via inflammatory mechanisms including complement activation. SLE may manifest itself in any organ system. In the eye, keratoconjunctivitis sicca is the most common finding. Other ophthalmic sites of involvement include the cornea, conjunctiva, episclera, sclera, uveal tract, retina, vasculature, optic nerve, and orbit. Therapy varies based on the disease manifestation and severity.

PMID:
15512979
DOI:
10.1080/09273940490895308
[Indexed for MEDLINE]

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