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Hematol Oncol Clin North Am. 2004 Dec;18(6):1379-403, ix.

Iron homeostasis and inherited iron overload disorders: an overview.

Author information

1
Department of Pediatrics, Harvard Medical School, USA. matthew.heeney@childrens.harvard.edu

Abstract

Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Recent discoveries of mutations in genes that lead to inherited iron overload diseases have advanced the understanding of iron homeostasis in humans. This article provides an overview of the human iron cycle, regulation of iron homeostasis, how perturbations in this homeostasis lead to iron overload disease in adults and children, and strategies for diagnosis of inherited iron overload.

PMID:
15511621
DOI:
10.1016/j.hoc.2004.06.018
[Indexed for MEDLINE]

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