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Cancer. 1992 Apr 1;69(7):1856-7.

Spontaneous regression of acquired immune deficiency syndrome-related, high-grade, extranodal non-Hodgkin's lymphoma.

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Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.


Spontaneous regression of low-grade non-Hodgkin's lymphoma often has been reported. Proposed mechanisms of this event have included concomitant infections and enhanced cellular and humoral antitumor responses by the host. Spontaneous regression of high-grade non-Hodgkin's lymphoma is rare and has never been reported in a patient with acquired immune deficiency syndrome (AIDS). The authors report a patient with spontaneous regression of AIDS-related non-Hodgkin's lymphoma and discuss the role of host immunity in mediating spontaneous regression.

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