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Nat Rev Cancer. 2004 Oct;4(10):806-13.

High interstitial fluid pressure - an obstacle in cancer therapy.

Author information

1
Ludwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden. C-H.Heldin@licr.uu.se

Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

PMID:
15510161
DOI:
10.1038/nrc1456
[Indexed for MEDLINE]

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