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Dermatology. 1992;184 Suppl 1:18-20.

Absorption of amorolfine through human nail.

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1
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.

Abstract

The percutaneous absorption of a new antifungal agent, amorolfine, has been measured through both skin and nail using an in vitro technique. Application of a 5% concentration in either an ethanol or methylene chloride lacquer resulted in permeation rates through nail in the range of 20-100 ng/cm2/h and somewhat higher through skin. Absorption was greater from the methylene chloride lacquer than the ethanol lacquer.

PMID:
1550966
[Indexed for MEDLINE]
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