Format

Send to

Choose Destination
J Med Chem. 2004 Nov 4;47(23):5593-6.

Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha.

Author information

1
Department of Medicinal Chemistry, X-Ceptor Therapeutics, Inc., 4757 Nexus Center Drive, San Diego, California 92121, USA.

Abstract

The estrogen-related receptor alpha (ERRalpha) is an orphan receptor belonging to the nuclear receptor superfamily. The physiological role of ERRalpha has yet to be established primarily because of lack of a natural ligand. Herein, we describe the discovery of the first potent and selective inverse agonist of ERRalpha. Through in vitro and in vivo studies, these ligands will elucidate the endocrine signaling pathways mediated by ERRalpha including association with human disease states.

PMID:
15509154
DOI:
10.1021/jm049334f
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center