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Thromb Res. 2004;114(5-6):539-45.

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.

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INSERM ERIT-M 0323 et EA 3452, Université Henri Poincaré, Boite Postale 184, 54505 Vandoeuvre-lès-Nancy, France.


The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (approximately 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies.

[Indexed for MEDLINE]

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