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Biochem Soc Trans. 2004 Dec;32(Pt 6):959-61.

Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.

Author information

1
The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK.

Abstract

PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair is well documented. Many anticancer therapies work by inducing breaks in DNA, if unrepaired these can lead to cell death. As PARP promotes DNA repair there is a strong rational to suggest that its inhibition may increase the efficiency of certain cytotoxic treatments. This review discusses the advances made in PARP inhibitor design and the mechanism by which they enhance anti-tumour therapies.

PMID:
15506935
DOI:
10.1042/BST0320959
[Indexed for MEDLINE]

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